BDBM50195497 (4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyridin-2-yl)-2,6-dimethylpiperazin-1-yl)methanone::CHEMBL441553

SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)c1ncccc1N

InChI Key InChIKey=IQEKKNIHTWIEQT-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195497   

Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
Affinity DataKi:  5nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
Affinity DataKi:  15nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by fluorescence polarization immuno-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed