BDBM50196514 CHEMBL3950881::US10167270, Example 00159
SMILES C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1
InChI Key InChIKey=NNXTWWKGCDOEQE-IBGZPJMESA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50196514
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.70nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 17nMpH: 7.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 7 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 22nMpH: 5.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of wild type recombinant human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubat...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Northwestern University Feinberg School of Medicine
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair