BDBM50198353 CHEMBL227753::CHEMBL534948::N-(2,6-dimethylphenyl)-5-[4-(1-methylpiperidin-3-ylmethoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine hydrochloride

SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1

InChI Key InChIKey=ZMNIUTKMAXSZLK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50198353   

TargetTyrosine-protein kinase Lck(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 20nMAssay Description:Inhibition of cSrc by coupled spectrophotometric enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 20nMAssay Description:Inhibition of cSrc by coupled spectrophotometric enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 530nMAssay Description:Inhibition of cSrc in COS7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Zap70More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198353(CHEMBL534948 | CHEMBL227753 | N-(2,6-dimethylpheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCbeta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed