BDBM50199661 CHEMBL240035::trans-3-(-4-(azetidin-1-ylmethyl)cyclohexyl)-1-(3-(benzyloxy)phenyl)imidazo[1,5-a]pyrazin-8-amine

SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1

InChI Key InChIKey=RLESQNUKOGTRMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50199661   

TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199661(trans-3-(-4-(azetidin-1-ylmethyl)cyclohexyl)-1-(3-...)
Affinity DataIC50: 81nMAssay Description:Inhibition of human recombinant GST-IGF1R activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199661(trans-3-(-4-(azetidin-1-ylmethyl)cyclohexyl)-1-(3-...)
Affinity DataIC50: 398nMAssay Description:Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed