BDBM50200930 CHEMBL3928423::US10087187, Compound 66

SMILES Cc1c(Nc2c(CO)nc3c(N)cc(nn23)N2CCOC(CO)C2)cccc1C(F)(F)F

InChI Key InChIKey=KHWGXDFXYVESQN-UHFFFAOYSA-N

Data  4 IC50  20 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50200930   

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataIC50: 43nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataIC50: 43nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataIC50: 79nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  138nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  138nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  138nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  138nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  355nMAssay Description:Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  355nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  355nMAssay Description:Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataIC50: 513nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.38E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  6.61E+3nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  6.61E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.10E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.35E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd: >3.02E+4nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd: >3.02E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent