BDBM50202098 CHEMBL218143::N-(1-hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide

SMILES OC12CC3CC(CC(C3)C1NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C2

InChI Key InChIKey=HDLZHQFBHVJHLK-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50202098   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataKi:  110nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataKi:  180nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against mouse 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against human 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed