BDBM50202656 CHEMBL3916438::US10730889, Example 419::US11485745, Example 419
SMILES CC1(COC1)OC(=O)N1CCC2(C[C@@H]2CNC(=O)N2Cc3ccncc3C2)CC1
InChI Key InChIKey=QFORHKAMQGBXQZ-QGZVFWFLSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50202656
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of NAMPT in human HT1080 cells assessed as decrease in cell viability after 96 hrs by CyQuant-Direct reagent based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP1A2 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.49nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of NAMPT in human HT1080 cells assessed as decrease in cell viability by measuring plasma protein binding corrected IC50 after 96 hrs by C...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.49nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP2C19 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair