BDBM50203455 CHEMBL3906151

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3noc(n3)-c3cncc(c3)-c3cnn(C)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=MANWCWXDWLXTDJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50203455   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50203455(CHEMBL3906151)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2018
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50203455(CHEMBL3906151)
Affinity DataIC50: 407nMAssay Description:Inhibition of CCDC6/RET (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2018
Entry Details Article
PubMed