BDBM50203526 (6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::(6S,7S)-N-hydroxy-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide::(6S,7S)-N-hydroxy-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL373532

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(=CC1)c1ccccc1

InChI Key InChIKey=SCOVLRMEIYKGOU-IRXDYDNUSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50203526   

LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  33nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  113nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  113nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  33nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  33nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  1.24E+3nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  3.88E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed