BDBM50209508 CHEMBL242983::N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phenylcarbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide

SMILES COc1ccc(CN2CCN(CC2)c2ccc(NC(=O)c3cc(OC)c(OC)cc3NC(=O)c3cnc4ccccc4c3)cc2)cc1OC

InChI Key InChIKey=KFUYKTYUJHLOPQ-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50209508   

TargetATP-dependent translocase ABCB1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataEC50:  29nMAssay Description:Inhibition of P-gp in human MES-SA/Dx5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataEC50:  59nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 393nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed