BDBM50210303 6-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)-prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole::CHEMBL445404

SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1cc(Cn3cncn3)ccc-21

InChI Key InChIKey=ZQAAOPZGDVVWQV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50210303   

TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210303(6-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 14nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210303(6-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 48nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210303(6-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210303(6-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed