BDBM50212000 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)phenyl)-1Hpyrazole-5-carboxamide::CHEMBL392934

SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1

InChI Key InChIKey=ZAMPINLTBPKGEY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50212000   

TargetVascular endothelial growth factor receptor 2(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50212000(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)ph...)
Affinity DataIC50: 48nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50212000(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)ph...)
Affinity DataIC50: 69nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50212000(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)ph...)
Affinity DataIC50: 380nMAssay Description:Inhibition of VEGFR1 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed