BDBM50213098 (R,R)-(-)-fenoterol::CHEMBL388570::US10617654, Compound (R,R)-1::US9492405, (R,R)-1::US9492405, 28

SMILES C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1

InChI Key InChIKey=LSLYOANBFKQKPT-UHFFFAOYSA-N

Data  8 KI  1 IC50  2 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50213098   

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataIC50: 0.140nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataEC50:  73nMAssay Description:Agonist activity beta2-adrenergic receptor in rat ventricular myocytes assessed as cell contraction following electrical stimulation by optical edge ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  345nM ΔG°:  -8.19kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKd:  347nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKd:  347nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  1.48E+4nM ΔG°:  -6.12kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  1.48E+4nMAssay Description:Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  3.45E+5nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Mouse)
Department Of Health and Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213098BDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  1.48E+7nMAssay Description:β1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent