BDBM50213114 (S,S)-(+)-fenoterol::CHEMBL389390::US10617654, Compound (S,S)-1::US9492405, (S,S)-1::US9492405, 31

SMILES C[C@@H](Cc1ccc(cc1)O)NC[C@H](c2cc(cc(c2)O)O)O

InChI Key InChIKey=LSLYOANBFKQKPT-UHFFFAOYSA-N

Data  7 KI  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50213114   

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataIC50: 184nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi:  3.37E+3nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi:  2.75E+4nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKd:  2.75E+4nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKd:  2.75E+4nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi:  2.77E+4nM ΔG°:  -5.77kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.07kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi:  2.77E+7nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Mouse)
Department Of Health and Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213114BDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataKi: >1.00E+8nMAssay Description:β1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent