BDBM50213120 (R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydroxyphenyl-beta-oxy)ethylaminopropane::CHEMBL228996::US10617654, Compound (R,S)-2::US9249163, 33::US9492405, (R,S)-2

SMILES COc1ccc(C[C@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1

InChI Key InChIKey=WHAUNCTVVNUUIP-UHFFFAOYSA-N

Data  8 KI  1 IC50  2 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50213120   

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 2.01nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataEC50:  506nMAssay Description:Agonist activity beta2-adrenergic receptor in rat ventricular myocytes assessed as cell contraction following electrical stimulation by optical edge ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.93E+3nM ΔG°:  -7.24kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKd:  1.95E+3nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKd:  1.95E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  3.07E+4nM ΔG°:  -5.72kcal/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Department Of Health And Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  3.08E+4nMAssay Description:Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.93E+6nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Mouse)
Department Of Health and Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50213120BDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  3.07E+7nMAssay Description:β1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent