BDBM50217552 CHEMBL339408

SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1

InChI Key InChIKey=KTQPEDAKIHCFGQ-SANMLTNESA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50217552   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50: >3.00E+3nMAssay Description:Displacement of [3H]rolipram from rat brain membrane suspensionsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Phosphodiesterase 3 extracted from dog aorta smooth muscle cells by using radioligands [3H]cAMP or [3H]-cGMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50217552(CHEMBL339408)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed