BDBM50218080 (4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-isopropylpyrrolidin-3-yl)methanone::CHEMBL399801

SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1)C(C)C)C(F)(F)F

InChI Key InChIKey=MWOKFIWZFMODNQ-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50218080   

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50218080((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50218080((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50218080((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50218080((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as cAMP accumulation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed