BDBM50219842 (S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide::CHEMBL246804

SMILES Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(c1N)C(F)(F)F)C(=O)NC(C)(C)C

InChI Key InChIKey=FQVOQFDNIZIQOT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50219842   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219842((S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-...)
Affinity DataIC50: 20nMAssay Description:Displacement of [125]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219842((S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at CCR2 in THP1 cells assessed as inhibition of MCP1-induced Ca2+ fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219842((S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219842((S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed