BDBM50219857 (S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide::CHEMBL398747

SMILES Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(c2N)C(F)(F)F)C(N)=O)c(C)c1

InChI Key InChIKey=FPRGMDNECUUAFV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50219857   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219857((S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-ox...)
Affinity DataIC50: 37nMAssay Description:Displacement of [125]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219857((S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-ox...)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at CCR2 in THP1 cells assessed as inhibition of MCP1-induced Ca2+ fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219857((S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-ox...)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219857((S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-ox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed