BDBM50220298 1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropylpiperidin-2-yl)cyclopropyl 4-(2-hydroxyethyl)piperazine-1-carboxylate::CHEMBL240069

SMILES OCCN1CCN(CC1)C(=O)OC1(CC1)[C@H]1CCC[C@@H](C2CC2)N1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=MZAPDYQWIGAEQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50220298   

TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220298(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50: 27nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220298(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed