BDBM50221546 4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL400303::US8481536, 541::US8481536, 618

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc12)-c1c(Cl)ccc(O)c1Cl

InChI Key InChIKey=ZWEHYQSGMOUIRZ-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50221546   

TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221546(4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  27nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221546(4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  27nMAssay Description:Binding affinity to Abl (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221546(4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  50nMAssay Description:Binding affinity to Abl-T315I mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50221546(4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataIC50:  8nMAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221546(4-(7-(2,6-dichloro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataIC50:  1.5nMT: 25°CAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent