BDBM50223325 1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(7-hydroxynaphthalen-1-yl)urea::CHEMBL249739

SMILES O=C(Nc1cccc2ccc(O)cc12)NC1CCc2cc(F)ccc2C1Cc1ccc(C(F)(F)F)cc1

InChI Key InChIKey=OKQJAECBEIPRAR-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50223325   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50223325BDBM50223325(1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50223325BDBM50223325(1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed