BDBM50225089 CHEMBL249771::N-((1-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)ethyl)piperidin-4-yl)methyl)morpholine-4-carboxamide

SMILES Cc1cc(C)cc(c1)-c1[nH]c2sc(cc2c1CCN1CCC(CNC(=O)N2CCOCC2)CC1)C(C)(C)C(=O)N1C2CCC1CC2

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50225089   

TargetGonadotropin-releasing hormone receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225089(N-((1-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2...)
Affinity DataIC50: 94nMAssay Description:Displacement of [125I]D-Trp from rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225089(N-((1-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2...)
Affinity DataIC50: 275nMAssay Description:Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225089(N-((1-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2...)
Affinity DataIC50: 743nMAssay Description:Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed