BDBM50225098 1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-morpholino-2-oxoethyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one::CHEMBL399772

SMILES Cc1cc(C)cc(c1)-c1[nH]c2sc(cc2c1CCN1CCN(CC(=O)N2CCOCC2)CC1)C(C)(C)C(=O)N1C2CCC1CC2

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50225098   

TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225098(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225098(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50: 110nMAssay Description:Displacement of [125I]D-Trp from rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225098(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50: 162nMAssay Description:Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225098(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50: 184nMAssay Description:Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed