BDBM50230031 CHEMBL4080914

SMILES COc1ccc2c3c1O[C@H]1[C@H](N(C)C(=O)/C=C/c4ccoc4)CC[C@@]4(O)[C@@H](C2)N(S(=O)(=O)c2ccccc2)CC[C@]314

InChI Key InChIKey=TYARCINDRAOWII-UHFFFAOYSA-N

Data  10 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50230031   

TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230031BDBM50230031(CHEMBL4080914)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human OX2 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed