BDBM50230033 CHEMBL4062717::US10377763, Example 34

SMILES COc1ccc2c3c1O[C@H]1[C@H](N(C)C(=O)/C=C/c4ccoc4)CC[C@@]4(O)[C@@H](C2)N(C(=O)C2CC2)CC[C@]314

InChI Key InChIKey=OZILLMNBXNRGSW-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50230033   

TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataKi:  12nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataIC50: 259nMAssay Description:The Chinese hamster ovary (CHO) cell lines CHOOX1R and CHOOX2R were established by modifying CHO cells to constantly express the NFAT-luciferase gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

US Patent
LigandChemical structure of BindingDB Monomer ID 50230033BDBM50230033(CHEMBL4062717 | US10377763, Example 34)
Affinity DataIC50: 1.00E+4nMAssay Description:The Chinese hamster ovary (CHO) cell lines CHOOX1R and CHOOX2R were established by modifying CHO cells to constantly express the NFAT-luciferase gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent