BDBM50230821 CHEMBL438744::c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2

SMILES NC(=O)[C@@H]1CCCCNC(=O)c2nccnc2C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1

InChI Key InChIKey=JJPMYGFCLXEQSM-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50230821   

TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataIC50: 412nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230821BDBM50230821(c[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 | CHEM...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed