BDBM50232443 CHEMBL4098611::US10214537, Example 303

SMILES CC(=O)N1CCN(CC1)c1cccc(c1)-c1cc(-c2ccnn2C2CC2)c2c(N)ncnn12

InChI Key InChIKey=CKNUTANRFRGJSU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232443   

LigandPNGBDBM50232443(CHEMBL4098611 | US10214537, Example 303)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232443(CHEMBL4098611 | US10214537, Example 303)
Affinity DataIC50:  2nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50232443(CHEMBL4098611 | US10214537, Example 303)
Affinity DataIC50:  681nMAssay Description:Inhibition of PI3Kdelta in BCR-stimulated human B cells assessed as suppression of CD86 expression after 18 hrs by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed