BDBM50232598 CHEMBL4084852

SMILES Cc1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1

InChI Key InChIKey=MMVNBNVFIIGGPC-AWEZNQCLSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50232598   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232598(CHEMBL4084852)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232598(CHEMBL4084852)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha3beta4 nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232598(CHEMBL4084852)
Affinity DataEC50:  120nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in HEK293 cells assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 3A(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232598(CHEMBL4084852)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human 5HT3A receptor assessed as inhibition of 5-HT-induced calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholine receptor subunit alpha/beta/delta/epsilon(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232598(CHEMBL4084852)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed