BDBM50232679 CHEMBL4068784::US11358936, Compound 4-5

SMILES NCc1ccnc(Cl)c1

InChI Key InChIKey=GGHCWJWUOSNCSK-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50232679   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Rattus norvegicus)
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  136nMAssay Description:Inhibition of full length recombinant rat LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 3(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  214nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged LOXL3 (1 to 753 residues) assessed as reduction in H2O2 production using DAP as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  5.91E+3nMAssay Description:Inhibition of full length recombinant human LOX expressed in HEK cells assessed as reduction in H2O2 production using DAP as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50: <300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  126nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Mus musculus)
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  227nMAssay Description:Inhibition of full length recombinant mouse LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells spiked into human whole blood assessed as reduction in H2O2 production using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232679(CHEMBL4068784 | US11358936, Compound 4-5)
Affinity DataIC50:  190nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed