BDBM50233154 CHEMBL4096134::US11124490, Compound 10

SMILES Fc1ccc(NC(=O)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc1F

InChI Key InChIKey=MWJJGNYTFWXXMM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50233154   

TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233154(CHEMBL4096134 | US11124490, Compound 10)
Affinity DataIC50: 31.5nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233154(CHEMBL4096134 | US11124490, Compound 10)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233154(CHEMBL4096134 | US11124490, Compound 10)
Affinity DataIC50: 528nMAssay Description:Inhibition of ATX (unknown origin) expressed in human A2058 cells assessed as inhibition of LPC-induced cell invasion after 20 hrs by calcein-AM dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233154(CHEMBL4096134 | US11124490, Compound 10)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent