BDBM50233155 CHEMBL4080953::US11124490, Compound 28b

SMILES CN1CCN(CC1)S(=O)(=O)c1cc(C(=O)Nc2cc(Cl)c(F)c(Cl)c2)c(Cl)cc1Cl

InChI Key InChIKey=WGYCFEGHYBMUIA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233155   

TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233155(CHEMBL4080953 | US11124490, Compound 28b)
Affinity DataIC50: 55.5nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetAutotaxin(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233155(CHEMBL4080953 | US11124490, Compound 28b)
Affinity DataIC50: 56nMAssay Description:Inhibition of ATX (unknown origin) expressed in human A2058 cells assessed as inhibition of LPC-induced cell invasion after 20 hrs by calcein-AM dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed