BDBM50233168 CHEMBL4085965::US11124490, Compound 11

SMILES Fc1cc(NC(=O)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc(F)c1F

InChI Key InChIKey=HBTSUJUYQYGOLI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50233168   

TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 9.32nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 396nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 1.03E+3nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of ATX (unknown origin) expressed in human A2058 cells assessed as inhibition of LPC-induced cell invasion after 20 hrs by calcein-AM dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233168(CHEMBL4085965 | US11124490, Compound 11)
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at LPA1 receptor (unknown origin) expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed