BDBM50233170 CHEMBL4073772::US11124490, Compound 13

SMILES Fc1ccc(NC(=S)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc1F

InChI Key InChIKey=GNWJALZHGZGSKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233170   

TargetAtaxin-1(Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50233170(CHEMBL4073772 | US11124490, Compound 13)
Affinity DataIC50:  67.3nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233170(CHEMBL4073772 | US11124490, Compound 13)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed