BDBM50233360 CHEMBL4062497

SMILES Cc1cc(ccc1Cl)[C@]12N(CCN1C(=O)c1ccccc21)C(=O)c1ccc(F)c(F)c1

InChI Key InChIKey=XMSLRELXMCKGCB-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50233360   

TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.18E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.20E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.20E+3nMAssay Description:Negative allosteric modulation of human M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.60E+3nMAssay Description:Negative allosteric modulation of rat M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.66E+3nMAssay Description:Negative allosteric modulation of rat M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human muscarinic M3 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50233360(CHEMBL4062497)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed