BDBM50233758 CHEMBL253883::tert-butyl (R)-1-((3-(1-cyclopropylethyl)-3H-imidazo[4,5-b]pyridin-2-yl)methylamino)-1-oxo-3-(2-(trifluoromethyl)phenyl)propan-2-ylcarbamate

SMILES CC(C1CC1)n1c(CNC(=O)[C@@H](Cc2ccccc2C(F)(F)F)NC(=O)OC(C)(C)C)nc2cccnc12

InChI Key InChIKey=IIZFMAZANLMCRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233758   

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233758(tert-butyl (R)-1-((3-(1-cyclopropylethyl)-3H-imida...)
Affinity DataIC50: 860nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233758(tert-butyl (R)-1-((3-(1-cyclopropylethyl)-3H-imida...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed