BDBM50234723 (2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone::CHEMBL255858

SMILES Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(c1ccccc1)c1cccnc1

InChI Key InChIKey=DDVVRHNNOPQPGB-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50234723   

TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  8.10nMAssay Description:Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  43.6nMAssay Description:Antagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  16.2nMAssay Description:Antagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234723((2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(ph...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed