BDBM50234723 (2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone::CHEMBL255858
SMILES Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(c1ccccc1)c1cccnc1
InChI Key InChIKey=DDVVRHNNOPQPGB-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50234723
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Antagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 43.6nMAssay Description:Antagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 16.2nMAssay Description:Antagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair