BDBM50234943 CHEMBL4099456::US10239861, Example 3

SMILES CN1CCCC(C1)Nc1cnn(C)c(=O)c1Cl

InChI Key InChIKey=LEPPHANDICKARV-UHFFFAOYSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50234943   

TargetBromodomain-containing protein 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234943(CHEMBL4099456 | US10239861, Example 3)
Affinity DataIC50: <5.01E+4nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234943(CHEMBL4099456 | US10239861, Example 3)
Affinity DataIC50:  85nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234943(CHEMBL4099456 | US10239861, Example 3)
Affinity DataIC50:  1.26E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair