BDBM50234944 CHEMBL4072538::US10239861, Example 60

SMILES CN1CCC[C@H](C1)Nc1cnn(C)c(=O)c1Cl

InChI Key InChIKey=LEPPHANDICKARV-MRVPVSSYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50234944   

TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50234944(CHEMBL4072538 | US10239861, Example 60)Copy SMILESCopy InChI

Affinity DataIC50: <5.01E+4nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In DepthDetails ArticlePubMed
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TargetNucleosome-remodeling factor subunit BPTF(Human)
University of Minnesota

Curated by ChEMBL

LigandBDBM50234944(CHEMBL4072538 | US10239861, Example 60)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

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In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetHistone acetyltransferase KAT2B(Human)
Genetech

US Patent

LigandBDBM50234944(CHEMBL4072538 | US10239861, Example 60)Copy SMILESCopy InChI

Affinity DataIC50:  235nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

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In DepthDetails US Patent
PDB3D Structure (crystal)
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TargetHistone acetyltransferase KAT2B(Human)
Genetech

US Patent

LigandBDBM50234944(CHEMBL4072538 | US10239861, Example 60)Copy SMILESCopy InChI

Affinity DataIC50:  501nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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