BDBM50235195 CHEMBL4087218

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2ccc(nc2)S(C)(=O)=O)CC1

InChI Key InChIKey=AJOOFYNEBGXCFI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50235195   

LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 226nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 226nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 240nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50: 6.00E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed