BDBM50236533 CHEMBL316388

SMILES C[C@@H]1CN([C@@H](C)CN1C(=O)c1ccc(cc1)C#N)C(=O)[C@@](C)(O)C(F)(F)F

InChI Key InChIKey=IWFSHKKFDSWNLZ-BWACUDIHSA-N

Data  3 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50236533   

LigandPNGBDBM50236533(CHEMBL316388)
Affinity DataIC50:  66nMAssay Description:Inhibition of PDHK1 in human PC3 cells assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Rattus norvegicus)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236533(CHEMBL316388)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity tested against Pyruvate Dehydrogenase Kinase (PDHK) receptor from rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236533(CHEMBL316388)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory activity against Pyruvate dehydrogenase kinase by primary enzymatic assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236533(CHEMBL316388)
Affinity DataEC50:  57nMAssay Description:In vivo inhibion of pyruvate dehydrogenase kinase, increased oxidation of lactateMore data for this Ligand-Target Pair