BDBM50237534 CHEMBL4091820

SMILES C[C@H]1COCCN1c1cc(nn2ccnc12)-c1ccc(NC(=O)Nc2ccncc2)cc1

InChI Key InChIKey=JDBFJYXPPSRGTL-INIZCTEOSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50237534   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Peking University

Curated by ChEMBL

LigandBDBM50237534(CHEMBL4091820)Copy SMILESCopy InChI

Affinity DataIC50:  62nMAssay Description:Inhibition of human N-terminal FLAG-tagged mTOR (1362-end residues) in presence of [gamma33P]ATP after 40 minsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Peking University

Curated by ChEMBL

LigandBDBM50237534(CHEMBL4091820)Copy SMILESCopy InChI

Affinity DataIC50:  3.11E+3nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI