BDBM50239167 CHEMBL1496110

SMILES CCOC(=O)N1CCC(CC1)c1cc(O)n2nc(C)c(-c3ccc(F)cc3)c2n1

InChI Key InChIKey=BFZOZLAMQAIRGP-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239167   

TargetShort transient receptor potential channel 3(Human)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  450nMAssay Description:Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 7(Human)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  497nMAssay Description:Agonist activity at human TRPC7 expressed in HEK293 cells assessed as increase in intracellular calcium level measured for 2.5 mins in presence of 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 7(Human)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  1.13E+3nMAssay Description:Agonist activity at human TRPC7 receptor expressed in HEK293 cells assessed as induction of channel current in presence of 0.1 mM Ca2+ by whole cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Mouse)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as induction of membrane potential de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Mouse)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as peak current changes at +80 mV by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Mouse)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  4.66E+3nMAssay Description:Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetShort transient receptor potential channel 4(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at mouse TRPC4 expressed in HEK293 cells coexpressing M5 receptor assessed as induction of TRPC4-mediated calcium influx by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Mouse)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Moe) and Hubei Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239167BDBM50239167(CHEMBL1496110)
Affinity DataEC50:  7.20E+3nMAssay Description:Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed