BDBM50239495 CHEMBL4076912::US10329302, Example 247::US10793579, Example 247::US11702424, Example 247

SMILES COc1cc2c(OC[C@H]3NC(=O)[C@@H](C)[C@H]3C)nccc2cc1C(N)=O

InChI Key InChIKey=LJNLHXYPMKVXJQ-ISTVAULSSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239495   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  2.84E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  29nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  29nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  29nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  29nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails US Patent