BDBM50242221 CHEMBL4084033

SMILES CCCCCC[C@H]1[C@@H](OC1=O)C(=O)NCCC[C@H](NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1

InChI Key InChIKey=FOAWQVCSTWCVPS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50242221   

TargetFatty acid synthase(Human)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50242221(CHEMBL4084033)
Affinity DataIC50: 160nMAssay Description:Inhibition of FAS thioster domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50242221(CHEMBL4084033)
Affinity DataIC50: 700nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50242221(CHEMBL4084033)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Z-Leu-Leu-Glu-AMC substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50242221(CHEMBL4084033)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of human FAS thioster domain preincubated for 30 mins followed by 4-methylumbelliferyl heptanoate substrate addition measured every 5 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50242221(CHEMBL4084033)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of trypsin-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Boc-Leu-Arg-Arg-AMC substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed