BDBM50242630 CHEMBL4089522
SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(F)cc2)c1
InChI Key InChIKey=UOHKZMQXEJGUES-HJWRWDBZSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50242630
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human full length His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of His6-tagged PARP12 (unknown origin) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP15(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 520nMAssay Description:Inhibition of His6-tagged PARP15 (unknown origin) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of His6-tagged PARP16 (unknown origin) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 562nMAssay Description:Inhibition of recombinant human full length His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against radioligand [3H](+)-NAN binding to haloperidol-sensitive sigma binding site in whole guinea pig brainMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human His6-tagged PARP5a catalytic domain (1091 to 1325 residues) expressed in Escherichia coli BL21(DE3) preincubated for ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of recombinant human His6-tagged PARP5a catalytic domain (1091 to 1325 residues) expressed in Escherichia coli BL21(DE3) preincubated for ...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 708nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair