BDBM50246424 2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]tetradeca-4(14),5,7-trien-3-yl}-N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-6'-yl]acetamide::CHEMBL455674

SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cccc5NC(=O)CCCn(c45)c3=O)cc2C1

InChI Key InChIKey=KEAKEOFPVQMZEM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246424   

LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed