BDBM50246466 (3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-5-methylpiperidine-3-carboxamide::CHEMBL452602

SMILES C[C@@H]1CNC[C@@H](C1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1

InChI Key InChIKey=SSMMYRQDZBSVCY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50246466   

TargetCyclin-dependent kinase 9(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246466((3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/Cyclin TMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246466((3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK2/Cyclin A by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246466((3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK7/Cyclin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246466((3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246466((3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK9-mediated RNA pol 2 phosphorylation at ser2 in human HCT116 cells after 16 hrs by HCS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed