BDBM50246951 CHEMBL4069930::US10570121, Example 45

SMILES Cc1cc(C)c(CN2CCc3c(Cl)cc([C@@H](CO)[C@H]4CCCO4)c(Cl)c3C2=O)c(=O)[nH]1

InChI Key InChIKey=MGRNSIQUUQNPAS-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246951   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246951BDBM50246951(CHEMBL4069930 | US10570121, Example 45)
Affinity DataKi:  103nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50246951BDBM50246951(CHEMBL4069930 | US10570121, Example 45)
Affinity DataIC50: 345nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246951BDBM50246951(CHEMBL4069930 | US10570121, Example 45)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed