BDBM50247149 5'-Methylthio-ImmH::CHEMBL473929::US9290501, (A)

SMILES CSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O

InChI Key InChIKey=CEGIKIXYDFDYDN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50247149   

TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50247149(5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A))
Affinity DataKi:  0.0760nM ΔG°:  -13.8kcal/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50247149(5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A))
Affinity DataKi:  2.70nMAssay Description:Inhibition of Plasmodium falciparum 3D7 PNP expressed in Escherichia coli assessed as reduction in uric acid formation by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247149(5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A))
Affinity DataKi:  101nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247149(5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A))
Affinity DataKi:  303nMAssay Description:Inhibition of human PNP expressed in Escherichia coli assessed as reduction in uric acid formation by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed